L-Carnosine is a naturally occurring product in our bodies.
But with the passage of time it decreases and this is believed
to be one of the primary factors leading to the aging process.
The human body has an optimum design factor of 120 years, but
few people live beyond their 80’s. This is why there is
so much excitement!! L-Carnosine, when introduced into the body's
cells, has been shown to rejuvenate the cells; in essence, it
is working as an anti-aging agent from within our cell structure.
Here’s what a scientific journal had to say. Please read
through and then I’ll tell you of its importance
to all Ethos members.
OF YOUTH” COMPOUND?
Well it looks that way! Recent studies are showing that L-Carnosine
(a dipeptide of two amino acids joined together..one being beta-alanine
and the other is L-histidine) is a major consideration in the
fight against aging and degenerative disease. Normally you make
it in your body and it appears mostly in muscles, heart, kidney
and brain cells. Interestingly, the most critical cells of aging.
In studies, the longer living animals had more of it in their
cells. With aging and time the amount decreases in human muscle
by 63% from age 10 to 70. And although science at this time
cannot tell us the total picture of why it
is there (we know some of its functions mentioned later) ..
they CAN say it is vital to survival and longevity.
The experiments went like
It started with the work in Australia. They wanted to see the effects
of L-Carnosine on cultured human cells. What they did
know were the results of decades of research on human cells and
the well-defined pattern in the growth, development and aging
of them, referred to as the “Hayflick Phenomenon”.
Placed in a growth vat with a fluid (medium) rich in essential
nutrients, cells from young donors will quickly begin to reproduce,
forming colonies, which fill the vat – and then stop reproducing,
to prevent starving themselves out. If half of these cells are
removed from the container, the remaining cells will begin growing
again to fill their environment.
But this process only goes on so far. At each round of division,
the cells are aging or becoming “senescent”.
The changes are subtle but as time goes on it becomes more and
more obvious that something is very wrong with the cells. They
lose their shape and begin to vary wildly in size, then fill
up with granular material, they stop forming continuous colonies,
losing their even, patterned, regular spacing and begin breaking
apart, with individual cells drifting off on their own. Senescent
cells stop producing the right proteins from their DNA, losing
the functions for which they were designed...the same process
which happens in skin aging and wrinkling. On
the whole, the appearance of the cell culture assumes an
unhealthy looking texture. Finally, after about 60 divisions,
the cells will stop reproducing and slide into a sort of twilight
zone, alive but inactive…simply waiting for death.
These are the known or given facts of the studies. Now here
is what happened. They raised lung and skin cells in one of
two standard cell culture mediums. Then they kept half of the
cells in the original medium, and transferred half to the same
medium supplemented with L-Carnosine. The results
were clear, simple and astonishing! The cells
in L-Carnosine not only had from 1 to 7 more
population doublings, the cells themselves lived up to two thirds
longer than the standard medium cells! L-Carnosine treated
cells had broken the Hayflick limit and left it in the dust!
In the whole person it would be like taking someone like Jean
Calmet who lived until 122 being the standard and having her
sister in the L-Carnosine group, surviving until 200 years old!
This is great...but the best news is that adding L-Carnosine
to the cell medium made the cells younger!
Scientists described the results as “striking effects
on the cell morphology" (shape and structure). The cells raised
in L-Carnosine-supplemented medium looked the same as they did
when they were young even over time, yet the ones raised in
the regular medium got old, blotchy , irregular and broke apart
into scattered islands of twisted debris.
It gets better…to take things one step further, the scientists
took the old, pooped-out cells from the standard medium and
put them into the L-Carnosine supplemented medium, and they
reversed this process by taking the L-Carnosine supplemented
cells and putting them in ordinary medium. Well, the first part
is not too hard to understand, the once L-Carnosine-supplemented
cells rapidly degenerated into what would be their normal state,
but the neatest part is that the “old” cells from
the normal medium were definitely made younger again by the
L-Carnosine bath!!!!! The researchers are quoted “These
cells showed a remarkable rejuvenation, with regard to their
morphology…..and finally reached ages significantly greater
than the control culture from which they were derived.”
Scientific establishments have subsequently repeated, confirmed
and expanded on the original results. They proceeded to show
that they could take regular cells, watch them age, put them
in the L-Carnosine bath, watch them grow younger and switch
them back and watch them age again. They propose that L-Carnosine
is integral to cellular organization and function, therefore
When L-Carnosine was taken from the petri dish to the lab and
studied on animals, the following findings were observed:
1) L-Carnosine enhanced the
memory functions of the brain cells and also stopped the over
stimulation of certain receptors...which in situations
such as stroke can inhibit oxygen to the brain cells leading
to cellular death.
2) It inhibits the activity of MAO B (monoamine
oxidase B) which is an enzyme involved in breaking down some
brain messengers (such as dopamine and serotonin). MAO B activity
is known to increase production of the free radical precursors
hydrogen peroxide, and the enzyme becomes more active as a person
gets older. Deprenyl, a drug used to treat people with Parkinson’s
disease, works by inhibiting MAO B.
3) Senile cataracts in 96 seniors, who had
them for 2-21 years improved greatly by using L-Carnosine eye
drops 3-4 times per day. Positive results were seen in over
80% of the cases. L-Carnosine was also seen to improve general
eyesight. Corneal ulcerations and erosion from viral and bacterial
sources also improved greatly.
4) In the first tests, it was noticed that
one of the batches of normal medium cells had become contaminated
with cancer cells. It was growing rapidly. When L-Carnosine
was added to this dying population, the cell cultures became
free of cancer cells! They tried it against seven different
human cancers and every one showed the same result. It seems
that as beneficial as L-Carnosine is to normal cells…it
was selectively toxic to human cancer cells!
is a highly versatile antioxidant capable of neutralizing a
large range of free radicals (superoxide, singlet oxygen, hydrogen
peroxide and both peroxyl and hydroxyl radicals). Further, it
has indirect antioxidant powers through chelation of pro-oxidant
metals and the prevention of the destruction of the antioxidant
enzyme superoxide dismutase. These qualities give it a place in
mercury and other heavy metal detoxification.
6) L-Carnosine protected cellular DNA better
than any other antioxidant (Vit E, Vit C, NAC etc) under the
stress of toxic levels of oxygen. In fact it was the only substance
7) L-Carnosine also protects against the formation
of Advanced Glycation Endproducts (AGE’s), proteins warped
by sugar (glycated). When a protein becomes glycated, it results
in the loss of that protein’s function, loss of flexibility,
atherosclerosis, abnormal cellular signaling, inflammation,
the complications of diabetes, and aspects of the aging process.
8) As people age, their rate of tearing down
old, defective cellular proteins (proteolysis) slows down, which
interferes with cellular function. L-Carnosine maintains proteolysis
at more youthful levels in old cells. It also reacts with abnormal
proteins, making it easier for the body to rid itself of them.
9) In some cases, L-Carnosine changes gene
expression in cells exposed to it, including increasing the
expression of vimentin, a protein involved in maintaining the
integrity and complex internal structure of the cell.
10) L-Carnosine enhances various aspects of
immunity and protects cells against damage from a variety of
toxins produced in the body as a part of normal metabolism such
as the lipid peroxidation product malondialdehyde; the cancer-causing
glycation product methylglyoxal; hypochlorite, a deadly substance
made by cells of the immune system to kill off invading pathogens,
but also toxic to the body’s own cells; formaldehyde’
and the amyloid beta-peptide, which forms the seed of the plaques
associated with Alzheimer’s. L-Carnosine also prevents
the development of amyloid into full-fledged plaques.
Serving Suggestions: Effectiveness starts at
around 900 – 1,000 mg per day. There are no adverse affects
from over-dosing as the excess is expelled naturally (water
soluble). When it is broken down by the enzymes in the body
it changes into two other essential nutraceuticals.
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L-Carnosine has not been evaluated by the
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